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Amarantus Announces Issuance of US Patent No. 10,195,251 Covering MANF Treatment of Wolfram's Syndrome, Retinitis Pigmentosa, and Glaucoma for Subsidiary MANF Therapeutics
Amarantus Announces Issuance of US Patent No. 10,195,251 Covering MANF Treatment of Wolfram's Syndrome, Retinitis Pigmentosa, and Glaucoma for Subsidiary MANF Therapeutics.
About this update from Amarantus Bioscience Holdings, Inc.
[{"type":"text","content":"\nNew York, NY, June 13, 2019 (GLOBE NEWSWIRE) -- via NEWEDIAWIRE -- Amarantus Bioscience Holdings, Inc. (OTC Pink: AMBS) (the “Company,” or AMBS), a US-based JLABS-alumnus biotechnology holding company developing first-in-class orphan neurologic, regenerative medicine and ophthalmic therapies and diagnostics through its subsidiaries, today announced that subsidiary MANF Therapeutics was issued U.S. Patent No. 10,195,251 entitled ‘Methods of Treatment for Retinal Diseases Using MANF and CDNF’ that covers the use of mesencephalic astrocyte-derived neurotrophic factor (MANF) or cerebral dopamine neurotrophic factor (CDNF) as a treatment for various ophthalmic disorders, including inherited retinal disorders (e.g. Retinitis Pigmentosa, Wolfram’s Syndrome, etc.), age-related macular degeneration and glaucoma. The approved claims cover the use of MANF or CDNF as an eye drop, as well as intravitreal injection. MANF Therapeutics is focused on the development of MANF as an intravitreal injection for the treatment of Wolfram’s Syndrome and Glaucoma.\n The ophthalmic therapeutic market is expected to reach $35B by 2025 according to Grand View Research, Inc. Glaucoma affects approximately 4 million people in the United States, with a total drug market size of approximately $3B. With its unique mechanism of action, MANF addresses key pathways in a variety of ‘back of the eye’ retinal conditions, which is an area with significant unmet medical need. MANF has significant therapeutic potential across multiple orphan ophthalmological conditions such as RAO, and retinitis pigmentosa, where MANF has already received orphan drug designations from the FDA, Wolfram’s Syndrome, as well as in larger indications such as glaucoma, Parkinson’s disease, diabetes and cardiovascular disease, including stroke and myocardial infarction. MANF Therapeutics is the front-runner and primary worldwide intellectual property (IP) holder for MANF-based therapies including protein therapy, gene therapy and cell therapy. The Company owns rights to composition of matter patents and patent applications for MANF and owns, or has licenses to, method of use patents and patent applications covering the use of MANF in ophthalmology, neurology and diabetes. Amarantus is currently evaluating strategi...