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Amarantus Announces Issuance of United States Patent Covering Proprietary Compositions of Matter and Methods of Use for Product Candidate MANF
Amarantus Announces Issuance of United States Patent Covering Proprietary Compositions of Matter and Methods of Use for Product Candidate MANF.
About this update from Amarantus Bioscience Holdings, Inc.
[{"type":"text","content":"\nSAN FRANCISCO and GENEVA, Aug. 20, 2015 (GLOBE NEWSWIRE) -- Amarantus BioScience Holdings, Inc. (OTCQX:AMBS), a biotechnology company developing therapeutic and diagnostic product candidates in orphan indications and neurology, announced that the U.S. Patent and Trademark Office (USPTO) issued U.S. Patent No. 9,115,208 entitled, \"Dopaminergic Neuronal Survival-Promoting Factors and Uses Thereof.\" The patent covers additional intellectual property protection for MANF (mesencephalic-astrocyte-derived neurotrophic factor) protein therapy and cell therapy. The patent covers compositions of matter and methods of use related to the Company's proprietary manufacturing process for synthetic MANF and its administration.\n\n\t\"The issuance of this key patent covering the proprietary compositions of matter and methods of use for MANF is very important to our intellectual property portfolio as we work towards the submission of a U.S. investigational new drug application for MANF for the treatment of retinitis pigmentosa over the course of the next 12-18 months,\" said Gerald E. Commissiong, President & CEO of Amarantus. \"We continue to advance our pre-clinical research and development programs for MANF in other orphan ophthalmological indications and in Parkinson's disease and believe this patent is key to building a robust patent estate with the ultimate goal of realizing MANF's full commercial potential in high value indications.\"\n\n\tNative MANF is currently under development for the treatment of orphan ocular indications, including retinitis pigmentosa (RP). Amarantus recently received both U.S. and European orphan drug designation for MANF for the treatment of RP. In addition to RP and Parkinson's disease, proof-of-concept preclinical models have also demonstrated that MANF proteins have the potential to treat a wide range of other conditions, including retinal artery occlusion, diabetes, ischemic heart disease and other chronic disorders.\n\n\tAbout Mesencephalic-Astrocyte-derived Neurotrophic Factor (MANF)\n\n\tMANF (mesencephalic-astrocyte-derived neurotrophic factor) is believed to have broad potential because it is a naturally-occurring protein produced by the body for the purpose of reducing and preventing apoptosis (cell death) in response to injury or disease, via the unfolded protein response. By manufacturing MANF...