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ALX Oncology Announces Updated Data from Ongoing Clinical Trial (ASPEN-01) of Evorpacept Showing Emerging Clinical Benefit in Survival-Based Endpoints in Patients with Advanced Solid Tumors
-- ORR of 72.2%, mDOR of 14.8 months, 12-month OS rate of 79%, and mOS of 17.1 months in Patients with >2L HER2 Positive Gastric/Gastroesophageal Junction
About this update from Alx Oncology Holdings Inc.
[{"type":"text","content":"-- ORR of 72.2%, mDOR of 14.8 months, 12-month OS rate of 79%, and mOS of 17.1 months in Patients with >2L HER2 Positive Gastric/Gastroesophageal Junction Cancer -- -- 12-month OS rate of 87.5% and mOS not reached in Patients with 1L Head and Neck Cancer -- -- 12-month OS rate of 80% and mOS of 24.5 months in Patients with Checkpoint Naïve >2L Head and Neck Cancer --__-- ALX Oncology to Host Conference Call on November 9 at 8:00 a.m. EST -- SOUTH SAN FRANCISCO, Calif., Nov. 09, 2021 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., (“ALX Oncology”) (Nasdaq: ALXO), a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced updated results from ASPEN-01, an ongoing evorpacept phase 1b study, evaluating patients with solid tumor malignancies at the Society for Immunotherapy of Cancer’s (“SITC”) 36th Anniversary Annual Meeting [abstract 498]. ALX Oncology reports updated results from both cohorts: the gastric/gastroesophageal junction cancer (“GC”) patient cohort receiving evorpacept plus trastuzumab plus chemotherapy, and from the head and neck squamous cell carcinoma (“HNSCC”) patient cohort receiving evorpacept plus pembrolizumab with and without chemotherapy. All data reflect response evaluable patients as of September 1, 2021. The SITC 36th Anniversary Annual Meeting poster is available to download under “Publications” in the Science section of the ALX Oncology website at www.alxoncology.com. In patients with >2L HER2 positive GC (n=18), evorpacept in combination with trastuzumab plus ramucirumab and paclitaxel demonstrated an initial objective response rate (“ORR”) of 72.2% with a median duration of response (“mDOR”) of 14.8 months, a 12-month overall survival (“OS”) rate of 79%, and a median overall survival (“mOS”) of 17.1 months. These results compare favorably with the clinical experience of both ramucirumab + paclitaxel and trastuzumab-deruxtecan in similar populations.In patients with 1L HNSCC who have not received prior treatment for their advanced disease (n=13), evorpacept demonstrates an initial ORR of 38.5% with a 12-month OS rate of 87.5% and mOS not reached in combination with pembrolizumab + 5FU + platinum. These results compare favorably with benchmark survival data from standard pembrolizumab + chemotherapy in the 1L HNSCC setting where ORR is a less reli...