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Altimmune Presents Data at EASL International Liver Congress™ 2024 Supporting the Disease Modifying Potential and Differentiated Therapeutic Profile of Pemvidutide in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Follow-on analyses of non-invasive tests from Phase 1 trials in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) suggest the potential for
About this update from Altimmune, Inc.
[{"type":"text","content":"Follow-on analyses of non-invasive tests from Phase 1 trials in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) suggest the potential for meaningful histologic improvements with MASH biopsy readouts in Q1 2025 Based on a quantitative systems pharmacology (QSP) computational model, pemvidutide’s GLP-1/glucagon dual agonism could have additive effects on MASH resolution and fibrosis improvement compared with GLP-1 alone Lipidomic profiling reinforces the disease modifying potential of pemvidutide on MASH and MASH-associated co-morbidities, including cardiovascular disease Pemvidutide is currently being evaluated in the ongoing Phase 2b IMPACT trial in subjects with MASH GAITHERSBURG, Md., June 05, 2024 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today presented new data on the potential anti-inflammatory and anti-fibrotic properties of pemvidutide in Metabolic Dysfunction-Associated Steatohepatitis (MASH) at the EASL International Liver Congress™ 2024 in Milan, Italy. “These data, coupled with MOMENTUM Phase 2 obesity trial results that showed class-leading lean mass preservation in body composition, further reinforce the opportunity for pemvidutide to distinguish itself broadly from approved therapies and other clinical candidates targeting MASH and obesity,” said Vipin K. Garg, Ph.D., President and Chief Executive Officer of Altimmune. “The balanced GLP-1 and glucagon dual agonism of pemvidutide represents a potentially differentiated approach to achieving clinically meaningful reductions in body weight, liver fat, and lipids to ameliorate MASH and address the many MASH-associated co-morbidities.” The data presented are summarized below: WED-212 (Abstract #3002): Pemvidutide treatment is associated with improvement in non-invasive tests indicating greater likelihood of histologic response in subjects with metabolic dysfunction-associated steatotic liver disease: a 24-week, randomized, double-blind, placebo-controlled trial 64 subjects who participated in the Phase 1 study of pemvidutide in MASLD were evaluated for changes in FibroScan®-AST (FAST) over 24 weeks of treatment. A subset of subjects with baseline ALT ≥ 30 IU/L were also evaluated for changes in MRI-PDFF and ALT scores.Up to 75% of subjects with intermediate-to-high risk of MASH progression (FAST ≥ 0....