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Teknova and Sartorius BIA Separations Announce Collaboration to Address Critical Pain Point in Gene Therapy Process Development
An AAV chromatography platform plus optimized custom buffer formulations yields a state-of-the-art offering for increased AAV recovery HOLLISTER, Calif.,
About this update from Alpha Teknova, Inc.
[{"type":"text","content":"An AAV chromatography platform plus optimized custom buffer formulations yields a state-of-the-art offering for increased AAV recovery\nHOLLISTER, Calif., March 15, 2023 (GLOBE NEWSWIRE) -- Alpha Teknova, Inc. (“Teknova”) (Nasdaq: TKNO), and Sartorius BIA Separations, which is part of the international life science group Sartorius, today announced that the companies have entered into a collaboration arrangement that will help gene therapy companies streamline the downstream purification process. Teknova is a leading producer of critical reagents for the research, discovery, development, and commercialization of novel therapies, vaccines, and molecular diagnostics, and Sartorius BIA Separations is a leading developer of monolith-based technologies for the separation and analysis of large biomolecules and viral particles. The collaboration highlights two essential components necessary for the successful recovery of empty and full AAV capsids during anion-exchange (AEX) purification: the separation technology and the buffer composition. With Sartorius BIA Separations’ proprietary AAV platform designed to optimize the separation of viral particles, and Teknova’s custom, high-quality buffer solutions developed to maximize capsid enrichment, the companies conducted a robust design of experiment (DOE) and successfully created a screening kit with optimized buffer formulations that drive consistency and increased purity when paired with the BIA CIMmultus® QA monolith. “We’re thrilled to find a like-minded partner with Sartorius BIA Separations, a well-respected, global leader in monolith-based technologies who shares our vision of making solutions possible,” said Stephen Gunstream, Teknova’s President and Chief Executive Officer. “Through our collaboration, we’re finding new tools to help our customers streamline the development of AAV therapies by optimizing their purification process and increasing the yield and purity of their AAV product.” “Teknova is the perfect partner for us as we explore robust, end-to-end solutions for our gene therapy customers seeking to achieve better results in the separation and analysis of viral particles,” added Aleš Štrancar, Managing Director at Sartorius BIA Separations. “Based on their ability to quickly manufacture high-quality, custom buffers that are consistent from batch to batch, we’ve been able...