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Allogene Therapeutics Announces 2024 Platform Vision to Redefine the Future of CAR T Led by ALPHA3, the Industry's First Pivotal Trial for Frontline Consolidation in Large B-Cell Lymphoma
Four Core Programs Leverage Unique Attributes in Product Development and Trial Design to Demonstrate the Unmatched Potential of an Allogeneic CAR T Large
About this update from Allogene Therapeutics, Inc.
[{"type":"text","content":"Four Core Programs Leverage Unique Attributes in Product Development and Trial Design to Demonstrate the Unmatched Potential of an Allogeneic CAR T Large B-Cell Lymphoma (LBCL): Groundbreaking ALPHA3 Trial has Potential to Leapfrog Other CAR Ts and Embed Cemacabtagene Ansegedleucel (Cema-Cel, Previously ALLO-501A) in First Line (1L) Treatment in Community Cancer Centers Where Most Newly Diagnosed Patients Seek CareChronic Lymphocytic Leukemia (CLL): New ALPHA2 Cohort Designed to Address a Limitation of Autologous Therapies in a Disease Where Poor T Cell Fitness is a Known Barrier to EfficacyAutoimmune Disease (AID): ALLO-329, Next-Generation CD19 Dagger™ Program will Focus on Scalability and Reduced or Chemotherapy-Free Lymphodepletion, Positioning Allogeneic CAR T to Transform Autoimmune Management and Meet the Demand of the MarketRenal Cell Carcinoma (RCC): Ongoing TRAVERSE Trial Advances Scientific Innovation Underlying Dagger™ Biology to Optimize CAR T Cell Expansion and Persistence Thereby Maximizing the Potential of Allogeneic CAR T in Solid Tumors While Mitigating Treatment-Associated Inflammatory Response Differentiated Potential for Cema-Cel to Boost Cure Rates in the 1L Setting Expected to Decrease Demand for Later Line Treatment, Effectuating De-Prioritization of Third Line ALPHA2 and EXPAND TrialsCompany to Focus Manufacturing in Cell Forge 1 to Prepare and Scale for Future AlloCAR T™ DemandPrioritization Will Streamline Resources, Reduce Cash Burn and is Expected to Extend Financial Runway Into 2026Conference Call Scheduled for Today at 2:00 PM PT/5:00 PM ET SOUTH SAN FRANCISCO, Calif., Jan. 04, 2024 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) products for cancer and autoimmune disease, today announced its 2024 Platform Vision that redefines the future of CAR T by leveraging the unique attributes of allogeneic CAR T products. “Until now, CAR T development has been defined by how autologous CAR Ts are made and used. As a management team with extensive experience in both autologous and allogeneic CAR Ts, and the only Company with the breadth of data to demonstrate comparability between the two, we are uniquely positioned to potentially redefine development and trial design of allogeneic CAR T products...