Aligos Therapeutics Presents Positive Data at the EASL Congress 2026

• Long-term follow up data from the Phase 1 study of pevifoscorvir sodium continues to suggest a reduction in the cccDNA reservoir
• Data on the preclinical characteristics of the Aligos/Amoytop ASO program to be presented
• 40% of HBeAg+ participants with chronic HBV infection treated with pevifoscorvir sodium at week 48 had reductions in HBsAg that would potentially allow them to qualify for ASO treatment

SOUTH SAN FRANCISCO, Calif., May 27, 2026 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on improving patient outcomes through best-in-class therapies for liver and viral diseases, today announced positive data from ten presentations at the European Association for the Study of the Liver (EASL) Congress 2026, being held May 27 – 30, 2026 in Barcelona, Spain.

“We are pleased to present positive data, including an investigator led study of ≥24 week follow up in HBeAg+ participants with nucleos(t)ide analogs (NAs) after 96 weeks of pevifoscorvir sodium monotherapy, which further supports our belief that we are reducing the cccDNA reservoir by activating the secondary mechanism of CAM-Es. By accessing this mechanism, we are also reducing HBsAg to a level that may allow additional patients to be eligible for functional cure therapy, including the ASO ALG-170675, being developed by Aligos and partner Amoytop,” stated Lawrence Blatt, Ph.D., M.B.A., Chairman, President, and Chief Executive Officer of Aligos Therapeutics. “Further, we will present data demonstrating that the combination of pevifoscorvir sodium and our antisense oligonucleotide ALG-170675 showed an additive to synergistic effects on reductions in HBV viral markers. Taken together, these data signal that pevifoscorvir sodium has the potential to not only replace NAs as the standard of care for chronic HBV infection but play a meaningful part in a functional cure regimen.”

Pevifoscorvir Sodium Post Treatment Data

Newly presented data highlight outcomes for treatment-naïve or currently not treated HBeAg+ subjects who completed 96 weeks of 300 mg pevifoscorvir sodium monotherapy, followed by ≥24 weeks of nucleos(t)ide analog (NA) monotherapy. Among HBeAg+ subjects, 9 of 10 subjects transitioned to NA monotherapy; of these, 4 (44%) maintained HBV DNA levels below the lower limit of quantification (LLOQ; 10 IU/mL, target detected [TD] or target not detected [TND]) throughout the NA only ≥24 week follow-up period. Reductions in HBV antigens and HBV RNA were maintained during the NA only ≥24 week follow-up period. Notably, these viral biomarkers, such as HBV antigens and HBV RNA, are typically unaffected by NA therapy, suggesting that pevifoscorvir sodium may reduce the cccDNA reservoir through engagement of its secondary mechanism of action.

In addition, newly presented data showed that among participants with a baseline HBsAg ≥3,000 IU/mL, 40% (4/10) achieved HBsAg