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Aligos Therapeutics Presents Clinical Data from NASH Program at the 2023 Paris Hepatology Conference
SOUTH SAN FRANCISCO, Calif., March 29, 2023 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused
About this update from Aligos Therapeutics, Inc.
[{"type":"text","content":"SOUTH SAN FRANCISCO, Calif., March 29, 2023 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in liver and viral diseases, today announced that the company presented Phase 1 data for its thyroid receptor-beta (THR-ß) agonist candidate, ALG-055009, at the 15th Paris Hepatology Conference, taking place virtually March 27 – 29, 2023. The presentation will be available on the Scientific Presentations and Conferences page on Aligos’ corporate website following the meeting. “We’re pleased to show at the conference that ALG-055009 has demonstrated a favorable safety and pharmacokinetic profile in healthy volunteers and subjects with hyperlipidemia,” said Lawrence Blatt, Ph.D., MBA, Chairman & CEO of Aligos Therapeutics. “Additionally, we also showed that, like the liquid formulation in earlier Phase 1 cohorts, the gelcap formulation had low variability and similar bioavailability and is well suited for use in the upcoming Phase 2 study. That study remains on track for a Q4 2023 regulatory filing.” Presentation title: The THR-beta Agonist ALG-055009 Has a Favorable Safety and Pharmacokinetic Profile and Dose Proportionally Lowers Lipid Biomarkers in a Phase 1 StudyPresenter: Matthew W. McClure, M.D., Chief Medical Officer, Aligos TherapeuticsPresentation date: Wednesday, March 29, 2023Presentation time: 15:55 – 16:40 CEST/10:55 – 11:40 a.m. ETSession title: R&D 2: The Drugs Pipeline Presented by CompaniesSummary: Data from the ongoing Phase 1 study ALG-055009-301 (NCT05090111) show that single ALG-055009 doses of up of 4 mg and multiple doses of up to 1 mg daily for 14 days were well tolerated in healthy volunteers and subjects with hyperlipidemia. ALG-055009 also showed favorable pharmacokinetic parameters after single and multiple doses, including dose-proportional increases in exposure for the liquid formulation and similar pharmacokinetic profiles for liquid and gelcap formulations of ALG-055009. Expected thyromimetic effects were also observed, including dose-proportional reductions in atherogenic lipids. About Aligos Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of liver and viral diseases. Aligos’...