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Aligos Therapeutics Initiates 12-Week Dosing Cohort in Phase 1b Study Evaluating Its Class II Capsid Assembly Modulator, ALG-000184
SOUTH SAN FRANCISCO, Calif., July 25, 2022 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on
About this update from Aligos Therapeutics, Inc.
[{"type":"text","content":"SOUTH SAN FRANCISCO, Calif., July 25, 2022 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today reported that enrollment in a 12-week dosing cohort of HBeAg-positive chronic hepatitis B (CHB) subjects was initiated in the ongoing Phase 1b study ALG-000184-201 (NCT04536337). “This is an important next step in our evaluation of ALG-000184 as a chronic suppressive therapy and/or part of a functional cure regimen in patients with CHB,” said Lawrence Blatt, Ph.D., MBA, CEO and Chairman of the Board at Aligos. “As we have shared at the recent International Liver Congress in London, oral ALG-000184 doses up to 100 mg given daily for 28 days were well tolerated with excellent pharmacokinetic properties and potentially best-in-class antiviral activity in both HBeAg-negative and -positive CHB subjects. With the initiation of this 12-week cohort at the 100 mg dose level, we can now explore whether longer-term dosing continues to be well tolerated and if greater suppression of important viral parameters, including HBV DNA and RNA, in HBeAg-positive subjects can be achieved. HBeAg-positive subjects are known to have much higher baseline HBV DNA and RNA levels compared to HBeAg-negative subjects and are consequently harder to treat. Based on the current rate of enrollment, we plan to share data from this important cohort at a scientific conference in Q4 2022.” About Aligos Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos’ strategy is to harness the deep expertise and decades of drug development experience its team has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules. Forward-Looking Statement This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform ...