Business
Alector Presents New Data from Multiple Pipeline Programs at 2021 CTAD Conference
SOUTH SAN FRANCISCO, Calif., Nov. 10, 2021 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering
About this update from Alector, Inc.
[{"type":"text","content":"SOUTH SAN FRANCISCO, Calif., Nov. 10, 2021 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering immuno-neurology, shared data from its AL003 and AL101 programs in poster presentations at the 14th Clinical Trials on Alzheimer's Disease (CTAD) conference being held November 9-12, 2021, virtually and in Boston. “Since our formation, Alector has established a deep pipeline of therapeutic immuno-neurology candidates, each of which aims to harness the body’s innate immune system to slow the progression of neurodegenerative diseases. The presentations at this year’s CTAD conference highlight the diverse genetically validated targets we have in our portfolio and the progress being achieved across our pipeline,” said Sam Jackson, interim Chief Medical Officer of Alector. “We’re presenting data from two Phase 1 clinical-stage candidates, AL003 and AL101, each with a distinct profile. AL003 has a mechanism analogous to the checkpoint inhibitors used in oncology and is intended to restore appropriate innate immune system function and allow the brain’s immune cells to do their job in maintaining a healthy equilibrium. AL101 builds on the success we’ve observed with our lead candidate, AL001, with the intent of offering optimized dosing while increasing progranulin levels. We will continue to advance both candidates into further clinical studies in the coming months.” Alector management will host a conference call to review and discuss data presented this week for four of its pipeline candidates at the CTAD conference and at the Society for Immunotherapy of Cancer (SITC) on November 12, 2021, at 4:00 p.m. ET. AL003: Phase 1 Data in Healthy Volunteers and Participants with Alzheimer’s DiseaseAL003 is a humanized monoclonal antibody that targets Siglec3 (sialic acid binding Ig-like lectin 3), or CD33, a transmembrane receptor expressed by microglia cells in the brain. The Phase 1 INTERCEPT (NCT03822208) study is a randomized, placebo-controlled trial evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of single and multiple doses of AL003 in healthy volunteers and patients with mild-to-moderate Alzheimer’s disease. In this first-in-human study, AL003 showed a favorable safety and pharmacokinetic profile for once-monthly intravenous dosing. AL003 demo...