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Akebia Therapeutics Announces First Participants Dosed in Phase 1 Clinical Trial of AKB-9090
AKB-9090 is being evaluated as a potential treatment for cardiac surgery-associated acute kidney injury CAMBRIDGE, Mass., April 13, 2026 (GLOBE NEWSWIRE) --
About this update from Akebia Therapeutics, Inc.
[{"type":"text","content":"AKB-9090 is being evaluated as a potential treatment for cardiac surgery-associated acute kidney injury\nCAMBRIDGE, Mass., April 13, 2026 (GLOBE NEWSWIRE) -- Akebia Therapeutics®, Inc. (Nasdaq: AKBA), a biopharmaceutical company with the purpose to better the lives of people impacted by kidney disease, today announced the first participants have been dosed in a Phase 1 clinical trial of AKB-9090, an internally developed hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor being evaluated for the treatment of cardiac surgery-associated acute kidney injury (AKI). The Phase 1 randomized, double-blind, placebo-controlled, single and multiple ascending dose (SAD/MAD) study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AKB-9090 administered intravenously in healthy adult participants. “AKB-9090 has been internally developed leveraging our team’s extensive expertise in HIF-PH biology, and we believe is a promising product candidate with the potential to treat acute care conditions with significant unmet need such as AKI,” said John P. Butler, Chief Executive Officer of Akebia. “We are pleased to have dosed our first study participants in the Phase 1 clinical trial and plan to report top line data in early 2027.” The trial will enroll up to 70 participants randomized to receive either AKB-9090 or placebo across sequential single and multiple dose-escalation cohorts. The primary endpoints include the incidence of treatment-emergent adverse events and changes in clinical laboratory parameters, vital signs, and electrocardiograms. More information about this study can be found here. In late 2025, Akebia introduced its pipeline of clinical stage kidney disease programs. In addition to AKB-9090, Akebia is evaluating praliciguat, a soluble guanylate cyclase stimulator, currently in a Phase 2 clinical trial targeting focal segmental glomerulosclerosis; and AKB-097, a next-generation tissue-targeted complement inhibitor planned to enter a Phase 2 basket trial in rare kidney diseases, including IgA nephropathy, lupus nephritis and C3 glomerulopathy, in the second half of 2026. About Akebia Therapeutics Akebia Therapeutics, Inc. is a fully integrated biopharmaceutical company with the purpose to better the lives of people impacted by kidney disease. Akebia was founded in 2007 and is headquart...