Company Expands Intellectual Property Portfolio TSX Venture Exchange: ARI TORONTO, Oct. 11 /CNW/ - ARIUS Research Inc. (TSX-VE: ARI) announced today that it has received a Notice of Allowance from the United States Patent and Trademark Office for a patent on its lead antibody, AR7BD-33-11A, targeting CD63. The patent is an important addition to the ARIUS intellectual property portfolio that underlies ongoing business development and licensing activities. This allowance covers the antibody molecule, various uses of the antibody, its derivatives, and a method for using it, and other similar antibodies, to treat cancers such as prostate and breast cancer. ARIUS has several additional patent applications pending that will continue to enhance the value of this important antibody asset. AR7BD-33-11A was generated through ARIUS' proprietary FunctionFIRST(TM) product platform. A series of anti-CD63 antibodies was produced over several years by using human cancer tissue samples as a source of cancer targets, and screening the resulting antibodies for their ability to kill cancer cells. ARIUS has shown that antibodies directed against the CD63 target have a significant impact on cancer. The AR7BD-33-11A lead antibody in the CD63 program has a broad spectrum of activity in animal models of human pancreatic cancer and melanoma as well as in breast and prostate cancers. The program has a number of antibodies with similar activity. Due to its potency, and other desirable characteristics, AR7BD-33-11A was selected as a lead antibody and humanized to make it suitable for human clinical trials. "Patents are crucial to a biotechnology company. They embody the value of the work we do and are one of the main reasons that other companies want to do business with us," commented Dr. David S. Young, President and Chief Scientific Officer of ARIUS. "We are working on obtaining partners for CD63 and other families of antibodies to help move them into clinical testing. Eventually we want our products to have a significant impact on patient outcomes in the same way other targeted therapies for cancer already have." About ARIUS Research ARIUS Research Inc. is a biotechnology company dedicated to personalizing cancer therapy through the discovery and development of novel anticancer monoclonal antibodies (MAbs). Established in 1999, ARIUS has built a proprietary technology platform, FunctionFIRST(TM), that rapidly identifies powerful MAbs targeting a variety of cancer indications. This antibody generation engine has enabled ARIUS to assemble a growing pipeline of over 300 functional MAbs, which may be used for commercial collaborations, out-licensing or in-house development. ARIUS has ongoing licensing and research partnerships with key biotechnology and drug development companies that provide revenues and access to external technologies. The long-term vision of ARIUS is to deliver personalized therapy by matching multiple antibodies to the distinct antigenic characteristics of each patient's tumour cells thereby increasing efficacy and avoiding side effects. Web site: www.ariusresearch.com The TSX Venture Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of this statement.
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