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Aeolus Announces Publication of Additional Data Demonstrating Efficacy of AEOL 10150 in Sulfur Mustard Exposure in Journal "Toxicological Sciences"
Aeolus Announces Publication of Additional Data Demonstrating Efficacy of AEOL 10150 in Sulfur Mustard Exposure in Journal "Toxicological Sciences".
About this update from Aeolus Pharmaceuticals Inc
[{"type":"text","content":"\nAeolus Announces Publication of Additional Data Demonstrating Efficacy of AEOL 10150 in Sulfur Mustard Exposure in Journal \"Toxicological Sciences\"\n\nAeolus Announces Publication of Additional Data Demonstrating Efficacy of AEOL 10150 in Sulfur Mustard Exposure in Journal \"Toxicological Sciences\"\n\nMISSION VIEJO, CA--(Marketwired - September 19, 2016) - TREATMENT WITH AEOL 10150 AFTER EXPOSURE TO SULFUR MUSTARD GAS --IMPROVED SURVIVAL AT 48 HOURS AFTER EXPOSURE FROM 36 PERCENT TO 88 PERCENTDECREASED AIRWAY CASTS AND RESTORED TGF-BETA AND SEVERAL OTHER MARKERS OF INFLAMMATION TO NORMAL VALUESIMPROVED BLOOD OXYGENATION AND CLINICAL SCORESDECREASED MARKERS OF OXIDATIVE STRESS Aeolus Pharmaceuticals, Inc. (OTCQB: AOLS), a biotechnology company developing compounds to protect against fibrosis, inflammation, nerve damage and infection, announced the publication of data confirming the efficacy of AEOL 10150 as a medical countermeasure against sulfur mustard gas inhalation. The data was recently published on-line in the journal Toxicological Sciences and is from studies performed by Brian Day, PhD, Vice Chair of Research at National Jewish Health in collaboration with the University of Colorado and the US Army Medical Institute for Chemical Defense and funded by the CounterACT Program, the National Institutes of Health Office of the Director, and the National Institute of Environmental Health Sciences. Aeolus is a biotechnology company with significant funding from the US government, focused on developing compounds to protect against radiological and chemical threats.The subject of the publication is a series of studies in a rat model of the acute effects of sulfur mustard gas on survival, breathing and a number of biomarkers for inflammation and fibrosis. In the study rats were exposed to lethal levels of sulfur mustard gas, which resulted in 64 percent of the untreated animals dying from the effects of the sulfur mustard gas within 48 hours of exposure. Survival for rats treated with AEOL 10150 improved dramatically in a dose depend manner. Animals administered AEOL 10150 every four hours, beginning one hour after exposure, had a survival rate of 88 percent at 48 hours. Treatment with AEOL 10150 also:Increased blood oxygen saturation by more than 10 percentImproved clinical scores of lung health by 57 percentDecreased airway c...