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Aeolus Announces Positive Data Confirming Efficacy of AEOL 10150 as a Medical Countermeasure Against Sulfur Mustard Gas
Aeolus Announces Positive Data Confirming Efficacy of AEOL 10150 as a Medical Countermeasure Against Sulfur Mustard Gas.
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[{"type":"text","content":"\nAeolus Announces Positive Data Confirming Efficacy of AEOL 10150 as a Medical Countermeasure Against Sulfur Mustard Gas\n\nAeolus Announces Positive Data Confirming Efficacy of AEOL 10150 as a Medical Countermeasure Against Sulfur Mustard Gas\n\nMISSION VIEJO, CA--(Marketwired - September 06, 2016) - AEOL 10150 DOUBLED SURVIVAL AT 28 DAYS AFTER EXPOSURE TO LETHAL SULFUR MUSTARD GASMEDIAN SURVIVAL TIME FOR ANIMALS TREATED WITH AEOL 10150 WAS 4.5 TIMES GREATER THAN UNTREATED ANIMALS Aeolus Pharmaceuticals, Inc. (OTCQB: AOLS), a biotechnology company developing compounds to protect against fibrosis, inflammation, nerve damage and infection announced the release of data confirming the efficacy of AEOL 10150 as a medical countermeasure against sulfur mustard gas inhalation. The new data are from studies performed by Brian Day, Ph.D., Vice Chair of Research at National Jewish Health in collaboration with the U.S. Army Medical Institute for Chemical Defense and funded by the CounterACT Program, the National Institutes of Health Office of the Director, and the National Institute of Environmental Health Sciences. In this most recent study, utilizing a new sustained-release formulation, 28 animals (14 control and 14 treated daily with AEOL 10150 for 28 days) were followed for 28 days after inhaled exposure to a lethal dose of sulfur mustard gas. The primary endpoint in the study was survival at 28 days and the secondary endpoint was median survival. Survival at 28 days in the AEOL 10150 treatment animals improved to 36 percent from 14 percent in the control group. Median survival improved from 4 days in the control group to 18 days in the AEOL 10150 treated group. There was also improvement in blood oxygenation in the AEOL 10150 treated group. These positive results build on data from prior acute and longer-term studies noted below:Sulfur Mustard Lung Program -- Highlights from Prior StudiesA prior 28 day study revealed that a 1.4mg/kg sulfur mustard gas exposure is 100% lethal by 20 days.In the prior 28 day study AEOL 10150 treatment every four hours for two days increased the median sulfur mustard survival from 2.8 days to 16 days with survival of AEOL10150 treated animals past 28 days.In acute 24 to 48 hour studies, AEOL 10150 treatment:significantly improved lung function 25% to normal levels in sulfur mustard exposed rats which cor...