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Adhera Therapeutics to Collaborate with Alberta Diabetes Institute, University of Alberta to Initiate Clinical Trial of MLR-1023 in Type 1 Diabetes
Adhera Therapeutics to Collaborate with Alberta Diabetes Institute, University of Alberta to Initiate Clinical Trial of MLR-1023 in Type 1 Diabetes.
About this update from Adhera Therapeutics Inc.
[{"type":"text","content":"\n Data will be instrumental in upcoming Phase 2 clinical trial of MLR-1023, Adhera’s novel Type 1 Diabetes drug candidateCompany moving forward with application to transition from OTC to NASDAQ Baton Rouge, LA, Jan. 25, 2023 (GLOBE NEWSWIRE) -- Adhera Therapeutics, Inc. (OTCQB: ATRX) (\"Adhera\" or the \"Company\"), a clinical stage biopharmaceutical company, is pleased to announce that the Company is to commence a dose finding study of MLR-1023 (tolimidone) in Type 1 Diabetes in collaboration with the Alberta Diabetes Institute (“ADI”) at the University of Alberta (“U of A”), located in Edmonton, Alberta, Canada. The Company and U of A are finalizing the details of the trial, which are expected to be released shortly. The results of the study will also be utilized to optimize the dose range used in Adhera’s forthcoming Phase 2 multi-center clinical trial of MLR-1023 in Type 1 Diabetes. It is anticipated that the ADI will also participate in the multi-center study. “The Alberta Diabetes Institute is Canada’s largest stand-alone research facility dedicated to translating discovery science into health solutions for the prevention and cure of diabetes and created the global standard for diabetes treatment with the Edmonton Protocol two decades ago. We are honored to be collaborating with an institution of this stature,” said Dr. Zahed Subhan, Chief Executive Officer of Adhera Therapeutics. “Given the pioneering work of Dr. Jean Buteau directed towards the identification of novel molecular mechanisms regulating beta-cell mass expansion in diabetes, the company believes that the Alberta Diabetes Institute is ideally positioned to continue development work on MLR-1023,” added Dr Subhan. MLR-1023, a lyn kinase activator with potent beta cell proliferation activity, has demonstrated exceptional clinical safety and tolerability in over 700 patients in Phase 2a and Phase 2b Type 2 diabetes studies. Adhera will focus its initial clinical trials on patients with Type 1 Diabetes where the Company can benefit from several factors, including the existing safety profile, which is expected to undergird the drug candidate moving directly into Phase 2 clinical trials and a shorter and less expensive clinical pathway compared to Type 2 Diabetes. Independent research has demonstrated...