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ADC Therapeutics Announces Updated Data from LOTIS-7 Phase 1b Clinical Trial of ZYNLONTA® in Combination with Bispecific Antibody Supporting Potential Best-in-Class Regimen in Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma
ADC Therapeutics SA (NYSE: ADCT), a commercial-stage global leader and pioneer in the field of antibody drug conjugates (ADCs), today announced updated data from the LOTIS-7 Phase 1b open-label clinical trial evaluating the safety and efficacy of ZYNLONTA® in combination with the bispecific antibody glofitamab (COLUMVI®) in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). The updated data is based on investigator assessment and reflects the 49 efficacy-evaluable pa
About this update from Adc Therapeutics Sa
[{"type":"text","content":"ZYNLONTA® in combination with glofitamab (COLUMVI®) demonstrated an 89.8% ORR and 77.6% CR across the 49 efficacy-evaluable patients with a minimum of 6 months of follow-up","length":172,"tagName":"p","attribs":{}},{"type":"text","content":"Combination continues to be generally well-tolerated with a manageable safety profile","length":85,"tagName":"p","attribs":{}},{"type":"text","content":"LOTIS-7 trial is on track for complete patient enrollment in 1H 2026; plan to share full data at a medical meeting and submit for publication by end of 2026","length":156,"tagName":"p","attribs":{}},{"type":"text","content":"Company to host conference call today at 8:00 a.m. EST","length":54,"tagName":"p","attribs":{}},{"type":"text","content":"LAUSANNE, Switzerland, Dec. 3, 2025 /PRNewswire/ -- ADC Therapeutics SA (NYSE: ADCT), a commercial-stage global leader and pioneer in the field of antibody drug conjugates (ADCs), today announced updated data from the LOTIS-7 Phase 1b open-label clinical trial evaluating the safety and efficacy of ZYNLONTA® in combination with the bispecific antibody glofitamab (COLUMVI®) in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). The updated data is based on investigator assessment and reflects the 49 efficacy-evaluable patients with a minimum of 6 months of follow-up from treatment initiation.","length":625,"tagName":"p"},{"type":"image","alt":"ADC Therapeutics logo (PRNewsfoto/ADC Therapeutics SA)","displaySize":"","headline":null,"caption":"ADC Therapeutics logo (PRNewsfoto/ADC Therapeutics SA)","className":"","disableSlideshowImg":false,"size":{"original":{"width":400,"height":250,"url":"https://media.zenfs.com/en/prnewswire.com/b45d5be0d129d2f2b168ba1839a068c7"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/xnw4DzeStakBHZIZhIV_hA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTcwNTtoPTQ0MTtjZj13ZWJw/https://media.zenfs.com/en/prnewswire.com/b45d5be0d129d2f2b168ba1839a068c7","width":400,"height":250}},"href":"https://mma.prnewswire.com/media/2543351/ADC_Therapeutics_SA__logo.html","hrefExternal":true,"rel":"nofollow"},{"type":"text","content":""We're excited that these data continue to demonstrate a manageable safety profile and strong efficacy including deep and durable responses in 2L+ r/r DLBCL patients treated with ZYNLONTA plus glofitamab," said Mohamed Zaki, MD, PhD, C...