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Adaptive Biotechnologies Announces New Data Highlighting the Clinical Relevance of MRD Testing with clonoSEQ® in Patients with Blood Cancers at the 65th ASH Annual Meeting
Treatment adapted studies show the potential for MRD assessment to guide the personalization of blood cancer careNew data demonstrates MRD assessed from blood
About this update from Adaptive Biotechnologies Corporation
[{"type":"text","content":"Treatment adapted studies show the potential for MRD assessment to guide the personalization of blood cancer careNew data demonstrates MRD assessed from blood in multiple myeloma may be an indicator of early response SEATTLE, Dec. 09, 2023 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (Nasdaq: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced new data demonstrating the expanding use of Adaptive’s next-generation sequencing (NGS)-based clonoSEQ® test in assessing minimal residual disease (MRD) in blood cancer patient care and in clinical trials. The data are being presented in more than 30 abstracts at the 65th Annual Meeting of the American Society of Hematology (ASH), December 9-12 in San Diego, California. Minimal residual disease, also known as measurable residual disease, refers to the residual malignant cells that can be present in the body after treatment at very low levels and can only be identified by highly sensitive tests. clonoSEQ, which is the only FDA-cleared test for MRD assessment in lymphoid malignancies, is highly accurate, sensitive, and standardized compared to other technologies used for disease burden assessment. “The already-substantial body of evidence supporting clonoSEQ’s prognostic value and clinical actionability is expanding in several important ways at ASH this year,” said Susan Bobulsky, Senior Vice President, Diagnostics, Adaptive Biotechnologies. “We are pleased to see many studies presented elucidating the role of clonoSEQ MRD testing in blood – both in multiple myeloma, where blood-based testing can expand patient access to MRD insights, and in a variety of subtypes of non-Hodgkin lymphoma, such as mantle cell lymphoma, where we see promising evidence of the role MRD may play in informing management.” Data generated from the University of Chicago found that MRD status determined through clonoSEQ testing of the peripheral blood (PB) early in treatment was prognostic, while stratification by complete response (CR) was not. The data were presented in a poster presentation titled, Early Peripheral Blood Minimal Residual Disease Status by NGS in Patients with Newly Diagnosed Multiple Myeloma (MM) on a Phase 2 Trial Receiving Elotuzumab, Carfilzomib, Lenalido...