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Acurx Pharmaceuticals Announces Presentation of Ibezapolstat Phase 2 Clinical Trial Results at ESCMID Global 2024 Scientific Conference
STATEN ISLAND, N.Y., May 2, 2024 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ: ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical
About this update from Acurx Pharmaceuticals, Inc.
[{"type":"text","content":"STATEN ISLAND, N.Y., May 2, 2024 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ: ACXP) (\"Acurx\" or the \"Company\"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that results from the ibezapolstat Phase 2 clinical trial in patients with C. difficile Infection (CDI) were presented at the 34th Congress of ESCMID Global (European Society of Clinical Microbiology and Infectious Diseases) on April 30th which was held in Barcelona, Spain, April 27-30, 2024.\n\nKevin Garey, PharmD, MS, FIDSA, Professor and Chair, University of Houston College of Pharmacy, Principal Investigator for microbiology and microbiome aspects of the ibezapolstat clinical trial program, and Acurx Scientific Advisory Board member gave an oral presentation entitled: A Phase 2, Randomized, Double-Blind Study of Ibezapolstat Compared with Vancomycin for the Treatment of Clostridioides difficile Infection. The presentation included additional analyses of clinical and microbiological data from the Phase 2b Segment of the trial.\nIn addition to Dr. Garey's oral presentation, Dr. Eugenie Basseres, Research Scientist, University of Houston College of Pharmacy presented a scientific poster entitled: Antibacterial activity of ibezapolstat against antimicrobial resistant clinical strains of Clostridioides difficile. Dr. Garey summarized the significance of these data presented and stated that: \"These findings show that ibezapolstat's unique mechanism of activity, inhibition of DNA polymerase IIIC, translates into in vitro activity against C. difficile strains with reduced susceptibility to fidaxomicin and vancomycin. As antimicrobial-resistant strains continue to emerge in the community, ibezapolstat will become a valuable therapeutic option.\"\nCommenting on his presentation, Dr. Garey stated: \"This randomized, active-controlled study showed ibezapolstat was comparable to vancomycin in achieving clinical cure in patients with mild-to-moderate CDI. Notably, no patients whose CDI was cured by ibezapolstat experienced recurrence of their disease within the 28-day follow-up period. These data reinforce earlier findings related to the anti-recurrence properties of ibezapolstat and warrant further development in Phase 3 trials with further microbiome studies planned to confi...