ABIONYX Pharma Achieves Major Milestone in apoA-I Biomanufacturing with Breakthrough in Synthetic Sphingomyelin Production

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[{"type":"text","content":"TOULOUSE, France & FULLERTON, Calif., March 27, 2026--(BUSINESS WIRE)--Regulatory News:","length":91,"tagName":"p"},{"type":"text","content":"ABIONYX Pharma, (FR0012616852 – ABNX – eligible for PEA PME), a next-generation biopharmaceutical company developing innovative therapies in sepsis and critical care based on an exclusive apoA-I technology platform, today announced a significant technological and industrial breakthrough combining high-performance apoA-I bioproduction with exclusive mastery of ultra-pure synthetic sphingomyelin, paving the way for a new class of sepsis therapeutics.","length":452,"tagName":"p"},{"type":"text","content":"A First-in-Class Scientific and Industrial Breakthrough","length":55,"tagName":"p"},{"type":"text","content":"As part of its strategy to enable large-scale industrial production of CER-001, ABIONYX Pharma has developed a new manufacturing process allowing:","length":146,"tagName":"p"},{"type":"list","items":[{"val":[{"type":"text","content":"A threefold increase in sphingomyelin production yield, one of the two key components of CER-001","length":96,"tagName":"p","attribs":{}}]},{"val":[{"type":"text","content":"A synthetic component with exceptional purity and structural quality, meeting the most stringent pharmaceutical standards.","length":122,"tagName":"p","attribs":{}}]}],"tagName":"ul","bulletedList":true,"length":218,"olType":false},{"type":"text","content":"All synthesis processes for this component are based on fully proprietary patents, providing ABIONYX Pharma with a major technological and competitive barrier.","length":159,"tagName":"p"},{"type":"text","content":"A Critical Component Mastered at the Highest Level","length":50,"tagName":"p"},{"type":"text","content":"Sphingomyelin is a strategic lipid widely recognized for its structural and functional properties. Within the CER-001 biomedicine, it plays a central role:","length":155,"tagName":"p"},{"type":"list","items":[{"val":[{"type":"text","content":"It stabilizes the ApoA-I protein in its optimal functional conformation","length":71,"tagName":"p","attribs":{}}]},{"val":[{"type":"text","content":"It gives CER-001 biological and therapeutic properties fully comparable to natural HDL found in the human body","length":110,"tagName":"p","attribs":{}}]},{"val":[{"type":"text","content":"It exhibits high intrinsic stability in...

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