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4D Molecular Therapeutics Reports First Quarter 2022 Financial Results and Provides Corporate Updates
EMERYVILLE, Calif., May 12, 2022 (GLOBE NEWSWIRE) -- 4D Molecular Therapeutics, Inc. (Nasdaq: FDMT), a clinical-stage biotherapeutics company harnessing the
About this update from 4d Molecular Therapeutics, Inc.
[{"type":"text","content":"EMERYVILLE, Calif., May 12, 2022 (GLOBE NEWSWIRE) -- 4D Molecular Therapeutics, Inc. (Nasdaq: FDMT), a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines, reported first quarter 2022 financial results and provided corporate updates. “We made significant progress in the first quarter of this year in moving several key programs of our diverse pipeline of clinical-stage genetic medicines,” said David Kirn, M.D., Co-founder and Chief Executive Officer of 4DMT. “In January, we announced treatment of the first patient with 4D-150 for wet AMD, and in February we presented compelling initial clinical data on 4D-310 for Fabry disease at the WORLD Symposium. In addition, we reported treatment of the first patient in our Phase 1/2 trial of 4D-710 for cystic fibrosis. Finally, we completed construction of our commercial-scale GMP manufacturing facility, which is expected to provide clinical trial material for our five product candidates across three therapeutic areas, and which underscores our phase-appropriate internal manufacturing strategy and commitment to capital stewardship. Our team is continuing to enroll multiple clinical trials for our product candidates, all of which use internally developed targeted and evolved vectors to unlock the full potential of genetic medicines for countless patients.” Recent Corporate Highlights Dosed the first patient in the Phase 1/2 clinical trial of 4D-710 in patients with cystic fibrosis. The Phase 1/2 clinical trial is a multicenter, open-label, dose-escalation and dose-expansion trial.Presented updated clinical data from the ongoing Phase 1/2 clinical trial of 4D-310 in patients with Fabry disease at the 18th Annual WORLDSymposium. The data presented demonstrated mean AGA enzyme activity was within, or significantly above, the normal range in all of the first three patients including patients with pre-existing high titer antibodies to AGA. Initial clinical data on cardiac imaging and cardiac-related quality-of-life endpoints suggested encouraging effects. In addition, 4D-310 had a manageable safety profile, without dose-limiting toxicity.Presented choroideremia natural history study data at the Association for Research in Vision and Ophthalmology (ARVO) annual meeting. The choroideremia natural history data show a strong correlation bet...