X0609 4 2026-10-15 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0001791058 Swayze Eric false 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP Research 0 Common Stock 2026-10-15 4 M 0 125 0.0 A 443 I by Son Common Stock 2026-10-16 4 S 0 53 43.5389 D 390 I by Son Common Stock 21759 D Restricted Stock Unit 0.0 2026-10-15 4 M 0 125 0.0 D Common Stock 125 486 I by Son Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award. The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. By: Patrick R. O'Neil, attorney-in-fact For: Eric Swayze 2026-10-19