X0609 4 2026-10-16 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan false C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true false false true CO-FOUNDER 1 Common Stock 221314 D Common Stock 2026-10-16 4 S 0 215 399.3403 D 8785 I By Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 280 401.2871 D 8505 I By Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 90 404.2528 D 8415 I by Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 50 405.1500 D 8365 I by Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 35 406.6250 D 8330 I by Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 80 409.3575 D 8250 I by Caraluna 1 Trust Common Stock 2026-10-16 4 S 0 142 398.9536 D 8858 I By Caraluna 2 Trust Common Stock 2026-10-16 4 S 0 280 400.6765 D 8578 I By Caraluna 2 Trust Common Stock 2026-10-16 4 S 0 60 401.6200 D 8518 I By Caraluna 2 Trust Common Stock 2026-10-16 4 S 0 90 403.6972 D 8428 I By Caraluna 2 Trust Common Stock 2026-10-16 4 S 0 80 406.0563 D 8348 I By Caraluna 2 Trust Common Stock 2026-10-16 4 S 0 98 409.3438 D 8250 I By Caraluna 2 Trust The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 11, 2026. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $399.0150 to $399.8500 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Held for the benefit of the beneficiaries of the trust. The Reporting Person disclaims beneficial ownership over such securities. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $400.8500 to $401.6200 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $404.0000 to $404.4550 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $409.0450 to $409.6700 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $398.8050 to $399.0950 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $400.1500 to $400.8850 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $403.4550 to $404.00 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $406.0000 to $406.1000 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $408.7800 to $409.7700 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Tami Chen, Attorney-in-Fact 2026-10-20